The Game Matchups Preview series is dedicated to breaking down how the Buffalo Bills match up with their opponent in every ...

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...

It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the ...

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

The San Francisco 49ers reportedly made a move on Friday. According to Eric Branch of The San Francisco Chronicle, the 49ers ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

First comes Brock Purdy, the team's star quarterback, who missed Week 12 with a right shoulder. While Purdy is still ...

Following new injury reports, updated simulations reveal the best bet for 49ers vs. Bills on Sunday Night Football. Injury ...

San Francisco 49ers star quarterback Brock Purdy has been given an injury update in time for their Week 13 match up against ...

The San Francisco 49ers are making changes to their WR group ahead of an important road trip to face the Buffalo Bills. The ...