The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five storylines to watch.

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to tell members of the Buffalo Bills’ locker room that 2024 was supposed to be a rebuilding year.

After its Week 11 party in Buffalo, "The NFL Today" crew is hitting the road again. This time, the NFL on CBS pregame show will broadcast live from Ford Field in anticipation of the Detroit Lions' Week 15 matchup against Josh Allen and the Buffalo Bills.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth.

Kansas City Chiefs quarterback Patrick Mahomes has been fined more than $14,000 for pantomiming what the NFL deemed a "violent gesture" during a game last week against the Buffalo Bills.

No table is safe at Orchard Park, and that includes any on the set of The NFL Today. Broadcasting outside of Highmark Stadium leading up to the most highly anticipated game on the Week 11 slate, the Kansas City Chiefs taking on the Buffalo Bills, The NFL Today crew endeared themselves to Bills Mafia by breaking an array of tables.

The Kansas City Chiefs will play the Buffalo Bills today. Here's everything you need to know to watch the game.

Following new injury reports, updated simulations reveal the best bet for 49ers vs. Bills on Sunday Night Football. Injury updates and betting insights point to Buffalo as the team to back.

The first big snow of the season threatened to bury towns in New York along lakes Erie and Ontario during a hectic holiday travel and shopping weekend.

Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, hips) and cornerback Deommodore Lenoir (knee) won’t play. Defensive tackle Jordan Elliott (concussion) also will be sidelined.